Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Accelerated folate breakdown in pregnancy

J McPartlin1, A Halligan, J M Scott

  • 1Department of Clinical Medicine, Trinity College Medical School, St James' Hospital, Dublin, Ireland.

Lancet (London, England)
|January 16, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of sulfasalazine and olsalamine on colonic epithelial cell folate content in patients with ulcerative colitis.

Inflammatory bowel diseases·2013
Same author

Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications.

Nutrition research reviews·2008
Same author

[The meaning and implementation of clinical governance].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2003
Same author

Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay.

British journal of cancer·2003
Same author

The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression.

International journal of gastrointestinal cancer·2003
Same author

Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up.

Gut·2002
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Pregnant women experience increased folate requirements due to enhanced folate breakdown. This study found higher levels of folate catabolites during pregnancy, indicating a greater daily dietary folate need than previously recommended.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Obstetrics

Background:

  • Pregnancy necessitates increased folate intake.
  • The underlying reasons for this heightened requirement are not fully understood.
  • Enhanced folate catabolism is a potential contributing factor.

Purpose of the Study:

  • To investigate whether increased folate catabolism contributes to the elevated folate requirements during pregnancy.
  • To quantify the rate of folate breakdown in pregnant women.

Main Methods:

  • Collected 24-hour urine samples from six pregnant women across trimesters and postpartum.
  • Utilized a defined diet to control nutrient intake.
  • Quantified folate breakdown products, p-amino-benzoylglutamate (pABGlu) and p-acetamidobenzoylglutamate (apBGlu), using high-pressure liquid chromatography.

Related Experiment Videos

Main Results:

  • Excretion of apBGlu significantly increased during the second trimester of pregnancy.
  • apBGlu levels returned to baseline postpartum.
  • The enhanced folate catabolism suggests an additional daily folate demand of 200-300 micrograms.

Conclusions:

  • Increased folate catabolism is a significant factor in the heightened folate requirements during pregnancy.
  • The estimated additional daily folate demand exceeds current recommendations.
  • This finding has implications for prenatal nutritional guidelines.