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Differential training sequence effect upon psychostimulant discrimination

M D Schechter1

  • 1Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|March 1, 1993
PubMed
Summary
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Rats trained with consecutive cathine administrations showed slower learning. However, consecutive cathinone administration did not impact learning speed, and neither drug showed tolerance effects on sensitivity (ED50).

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Previous research suggests rapid tolerance may diminish drug discriminative performance.
  • This tolerance could impair performance when rats are trained with consecutive drug administrations compared to non-consecutive ones.

Purpose of the Study:

  • To investigate if consecutive administrations of cathinone or cathine during training impact learning speed and sensitivity in rats.
  • To test the hypothesis that consecutive drug exposure leads to poorer performance compared to spaced administrations.

Main Methods:

  • Rats were trained using an operant task with either 1-cathinone (0.8 mg/kg) or d-cathine (4.8 mg/kg).
  • Each drug group was divided into subgroups: one receiving consecutive drug administrations, the other receiving non-consecutive administrations.

Related Experiment Videos

  • Performance was assessed by training time (sessions-to-criterion) and drug sensitivity (ED50 values).

    • Main Results:

    • Consecutive cathine administration significantly increased training time (sessions-to-criterion) compared to non-consecutive administration.
    • Consecutive cathinone administration did not significantly affect training time.
    • No significant differences in ED50 values were found between differentially trained groups for either drug.

    Conclusions:

    • Consecutive cathine administration may slow acquisition but does not affect drug sensitivity.
    • Cathinone does not appear to induce tolerance that affects learning speed or sensitivity with consecutive administration.
    • There is no direct correlation between the speed of learning (acquisition) and drug sensitivity (ED50) in this context.