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Mapping of a rat multidrug resistance gene by fluorescence in situ hybridization
N C Popescu1, J A Silverman, S S Thorgeirsson
1Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Genomics
|January 1, 1993
Abstract:
A cDNA clone encoding the rat mdr1b (Pgy2) gene was recently isolated and characterized. This gene has a high degree of sequence identity with other Pgy genes, particularly the mouse Pgy2 gene. By means of in situ fluorescence hybridization, the rat Pgy gene was localized on chromosome 4 band q12. This regional mapping will facilitate the identification of synteny groups on rat, mouse, and human genomes and chromosomal rearrangements during mammalian evolution.