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CSF somatostatin in obsessive-compulsive disorder

M Altemus1, T Pigott, F L'Heureux

  • 1Laboratory of Clinical Science, NIMH, Bethesda, MD.

The American Journal of Psychiatry
|March 1, 1993
PubMed
Summary
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Patients with obsessive-compulsive disorder (OCD) show higher cerebrospinal fluid (CSF) somatostatin levels compared to healthy individuals. This suggests a potential role for somatostatin in OCD symptoms and treatment response.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biochemistry

Background:

  • Central somatostatin administration in animals can induce behaviors resembling obsessive-compulsive disorder (OCD) compulsions.
  • Serotonin reuptake inhibitors, a common OCD treatment, may decrease brain somatostatin levels.

Purpose of the Study:

  • To investigate central somatostatin activity in patients diagnosed with obsessive-compulsive disorder.
  • To explore the relationship between somatostatin levels and OCD symptomatology.

Main Methods:

  • Cerebrospinal fluid (CSF) samples were collected from 15 drug-free outpatients with OCD.
  • CSF samples were also collected from 27 healthy volunteers for comparison.
  • Somatostatin levels in CSF were measured in all participants.

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Main Results:

  • Mean CSF somatostatin levels were significantly elevated in patients with OCD compared to normal subjects.
  • This finding was particularly noted in patients with predominant symptoms of perseverative thought processes.

Conclusions:

  • Elevated CSF somatostatin may play a role in the clinical presentation of obsessive-compulsive disorder.
  • These findings suggest somatostatin's involvement in the neurobiology of OCD and its response to pharmacotherapy.
  • The results contrast with low CSF somatostatin levels observed in disorders with significant cognitive deficits.