Use of adrenergic agonists during CPR in adults

Adrenergic therapy is indicated during CPR to increase the coronary and cerebral perfusion pressure. Epinephrine hydrochloride at a dosage of 1.0 mg has been the most commonly used adrenergic agonist for resuscitation of adults, but there has been considerable controversy over whether higher doses should be given. At the 1992 National Conference on Emergency Cardiac Care and CPR, preliminary data were presented from three large, prospective, blinded, unpublished clinical trials that included a comparison of standard-dose (0.02 mg/kg or approximately 1.0 mg) and high-dose (approximately 0.1-0.2 mg/kg) epinephrine in 2,415 adults. Although the studies differed from each other somewhat in design, the results were remarkably consistent across all three studies: there was no difference in survival between the standard- and high-dose epinephrine regimens. There were no consistent adverse effects associated with the use of higher-than-standard doses of epinephrine. The consensus of the Adrenergic Agonist Panel was that: 1) epinephrine by i.v. bolus should remain the drug of choice for use during resuscitation in adults; 2) data presented from the clinical trials in adults do not support an increase in the recommended dose of epinephrine; 3) because there was no evidence of significant harm from the use of high-dose epinephrine, it was felt that use of such dosages should receive a II-b recommendation pending the results of further ongoing clinical trials; 4) the standard i.v. bolus dosage of epinephrine should be simplified to 1.0 mg every three to five minutes; and 5) the endotracheal dosage of epinephrine should be at least 2 to 2.5 times larger than the peripheral i.v. dosage.