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"Infectious" transplantation tolerance

S Qin1, S P Cobbold, H Pope

  • 1Department of Pathology, University of Cambridge, United Kingdom.

Science (New York, N.Y.)
|February 12, 1993
PubMed
Summary
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Researchers investigated transplantation tolerance in mice using antibody treatments. Tolerant T cells spread this tolerance to new cells, explaining long-term graft acceptance without ongoing immunosuppression.

Area of Science:

  • Immunology
  • Transplantation Biology

Background:

  • Maintaining transplantation tolerance is crucial for graft survival.
  • Short-term immunosuppression can induce long-lasting tolerance.

Purpose of the Study:

  • To investigate the mechanisms maintaining transplantation tolerance induced by short-term antibody treatment.
  • To understand how tolerance is sustained without continuous immunosuppression.

Main Methods:

  • Adult mice received short-term nonlytic monoclonal antibody treatment targeting CD4 and CD8.
  • Analysis of T cell populations and their function in tolerant recipients.

Main Results:

  • T cells from tolerant mice could disable naive lymphocytes, preventing graft rejection.

Related Experiment Videos

  • This disabling effect was transferable, inducing tolerance in naive lymphocytes.
  • A process termed "infectious" tolerance was identified.

    • Conclusions:

    • "Infectious" tolerance mediated by CD4+ T cells explains the long-term maintenance of transplantation tolerance.
    • This mechanism obviates the need for continuous immunosuppression after initial induction.