Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lymphocyte defects in chronic osteomyelitis. A prospective study]

K M Peters1, B Klosterhalfen, G Zwadlo-Klarwasser

  • 1Orthopädische Klinik, RWTH, Aachen.

Der Unfallchirurg
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are late hernia mesh complications linked to Staphylococci biofilms?

Hernia : the journal of hernias and abdominal wall surgery·2022
Same author

Biofilms and effective porosity of hernia mesh: are they silent assassins?

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

[Conservative treatment of atraumatic femoral head necrosis].

Der Orthopade·2018
Same author

Effects of ovarian fluid and genetic differences on sperm performance and fertilization success of alternative reproductive tactics in Chinook salmon.

Journal of evolutionary biology·2017
Same author

[Compliance of osteoporosis patients with additional specific osteoporosis-training course].

Der Orthopade·2016
Same author

The use of the chorio-allantoic membrane of the chick embryo as test for anti-inflammatory activity.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2016

Chronic osteomyelitis shows minimal impact on lymphocyte subsets in blood and bone tissue. However, osteomyelitis may impair lymphocyte and macrophage cooperation, affecting immune response.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Bone Biology

Context:

  • Chronic post-traumatic osteomyelitis presents complex challenges in treatment.
  • Understanding the host's immune response is crucial for managing persistent infections.
  • Previous studies suggested significant immune dysregulation in osteomyelitis patients.

Purpose:

  • To investigate the immunological status of patients with chronic post-traumatic osteomyelitis.
  • To analyze lymphocyte subsets in peripheral blood and infected bone tissue.
  • To explore potential immune defects contributing to osteomyelitis pathogenesis.

Summary:

  • A prospective study analyzed 20 patients with chronic osteomyelitis.
  • Histological examination revealed only slight alterations in peripheral blood and bone tissue lymphocyte subsets.

Related Experiment Videos

  • Interleukin-2 receptor expression was largely absent in infected tissues, suggesting potential immune cell dysfunction.

    • Impact:

    • Findings indicate that chronic osteomyelitis may not profoundly alter lymphocyte subsets.
    • A potential defect in lymphocyte/macrophage cooperation is suggested as a contributing factor.
    • This research provides insights into the complex immune interactions in osteomyelitis, guiding future therapeutic strategies.