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The neuroendocrine-immune axis

F Homo-Delarche¹, M Dardenne

¹CNRS URA 1461, Hôpital Necker, Paris, France.

Springer Seminars in Immunopathology

|January 1, 1993

Summary

The nervous, endocrine, and immune systems are interconnected, forming a complex network. Recent research reveals bidirectional communication, with the immune system influencing the neuroendocrine system and vice versa.

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Area of Science:

Neuroimmunology
Neuroendocrinology
Physiology

Background:

Homeostasis is maintained by the nervous, endocrine, and immune systems.
The neuroendocrine system modulates immune responses.
The immune system can act as a neuroendocrine organ, producing hormones and cytokines.

Purpose of the Study:

To explore the intricate interrelationships between the nervous, endocrine, and immune systems.
To highlight the bidirectional communication within this network.

Main Methods:

Review of established neuroendocrine-immune interactions.
Analysis of recent findings on immune system's neuroendocrine functions.
Examination of cytokine effects on the nervous system and cytokine production within the brain.

Main Results:

Cytokine receptors are present in the nervous system.
Cytokines influence nervous system functions like growth, neuromodulation, fever, sleep, and appetite.
Nervous system cells produce cytokines.
The brain is not immunologically isolated, allowing immune responses within the blood-brain barrier.

Conclusions:

The nervous, endocrine, and immune systems form a tightly integrated network with bidirectional communication.
The immune system plays a significant role in neuroendocrine regulation and vice versa.
The brain's immune privilege is not absolute, with immune responses occurring within the central nervous system.

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