Effects of thiotepa on the productivity of male Aedes aegypti

The effects of various concentrations of thiotepa, a chemomutagen, on the genetic fitness of Aedes aegypti males was studied. Oral treatments of 0.025 percent, 0.050 percent and 0.075 percent thiotepa induced sexual sterility in the male mosquitoes. Analyses of total F2 productivity indicate that the mean number of progeny was significantly decreased with exposure to 0.001 percent of the chemomutagen. At 0.001 percent thiotepa only a mean of 198.04 F2 progeny per culture were produced; by comparison the control group gave 315.33.