Related Experiment Video
Updated: May 7, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Collagenous colitis in children
D A Gremse1, C W Boudreaux, E A Manci
1Division of Pediatric Gastroenterology and Nutrition, University of South Alabama College of Medicine, Mobile.
Insights
Collagenous colitis is a rare condition in children causing chronic diarrhea. This case report details an 8-year-old girl whose symptoms resolved with corticosteroid treatment, highlighting its importance in pediatric diagnosis.
Area of Science:
- Gastroenterology
- Pediatric Pathology
Background:
- Collagenous colitis is a rare gastrointestinal disorder.
- It is characterized by subepithelial collagen deposition and lamina propria inflammation.
- Infrequent reports exist in pediatric populations.
Observation:
- An 8-year-old female presented with chronic watery diarrhea and abdominal pain.
- Colonic mucosal biopsy confirmed the pathological features of collagenous colitis.
Findings:
- The patient's symptoms of chronic diarrhea and abdominal pain resolved after corticosteroid therapy.
- This suggests a potential therapeutic response to corticosteroids in pediatric collagenous colitis.
Implications:
- Collagenous colitis should be considered in the differential diagnosis of chronic diarrhea in children.
- Early diagnosis and treatment may improve patient outcomes.
- Further research into pediatric collagenous colitis is warranted.
Abstract:
Collagenous colitis, a disorder characterized by increased subepithelial collagen deposition associated with an inflammatory infiltrate in the lamina propria, has been reported infrequently in children. An 8-year-old girl with collagenous colitis is described who presented with chronic watery diarrhea and abdominal pain. Biopsy specimens of the colonic mucosa showed the pathological features of collagenous colitis. The patient's symptoms resolved following corticosteroid therapy. Collagenous colitis should be considered in the differential diagnosis of children with chronic diarrhea.
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Introduction
Inflammatory Bowel Disease II: Ulcerative Colitis
Diverticular Disease of the Colon

