Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A nonrandom interneuronal pattern in the developing frog spinal cord

R D Heathcote1, A Chen

  • 1Department of Biological Sciences, University of Wisconsin, Milwaukee 53201.

The Journal of Comparative Neurology
|February 15, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of a Charmed Baryon Decaying to D;{0}p at a Mass Near 2.94 GeV/c;{2}.

Physical review letters·2007
Same author

Observation of CP violation in B --> eta'K0 decays.

Physical review letters·2007
Same author

Observation of time-dependent CP violation in B0 --> eta'K0 decays and improved measurements of CP asymmetries in B0 --> phiK0, KS0KS0KS0 and B0 --> J/psiK0 decays.

Physical review letters·2007
Same author

Vector-tensor and vector-vector decay amplitude analysis of B0-->phiK*0.

Physical review letters·2007
Same author

Observation of B-->eta'K* and evidence for B+-->eta'rho+.

Physical review letters·2007
Same author

Measurement of the CP asymmetry and branching fraction of B0-->rho0K0.

Physical review letters·2007
Same journal

Inhibitory Neurons in Human Anterior Entorhinal Cortex and Some Comparisons With the Rhesus Monkey.

The Journal of comparative neurology·2026
Same journal

In Situ Hybridization Chain Reaction and Immunohistochemical Labeling of the Octopamine Production Pathway in the Central Nervous System of Lymnaea stagnalis.

The Journal of comparative neurology·2026
Same journal

Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.

The Journal of comparative neurology·2026
Same journal

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula.

The Journal of comparative neurology·2026
Same journal

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

The Journal of comparative neurology·2026
Same journal

Brain Distribution of Orthopedia (Otp) Transcription Factor in Bony Fish: A Comparative Neuroanatomical Perspective.

The Journal of comparative neurology·2026
See all related articles

Newly discovered catecholaminergic neurons in Xenopus laevis form organized spinal cord columns. Their non-random spacing suggests neighbor-exclusion governs their precise arrangement.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The developing nervous system exhibits complex cellular organization.
  • Interneurons play crucial roles in neural circuit function.
  • Understanding neuronal patterning is key to developmental neuroscience.

Purpose of the Study:

  • To describe a novel organizational pattern of interneurons in the developing frog spinal cord.
  • To characterize the neurochemical identity and spatial distribution of these neurons.
  • To investigate the principles governing their cellular arrangement.

Main Methods:

  • Glyoxylic acid treatment for catecholamine visualization.
  • Immunocytochemistry using tyrosine hydroxylase antibodies.
  • Spatial analysis of cellular distribution in the larval spinal cord.

Related Experiment Videos

Main Results:

  • Identified catecholaminergic interneurons in the floor plate of Xenopus laevis larvae.
  • These neurons are cerebrospinal fluid-contacting and project towards the brain.
  • Their spatial distribution is non-random, forming two longitudinal columns with neighbor-exclusion, lacking segmental repeats.

Conclusions:

  • A previously undescribed level of neuronal organization exists in the developing spinal cord.
  • Catecholaminergic neuron patterning is influenced by cell-cell interactions, specifically exclusion.
  • This study reveals fundamental principles of neuronal spatial self-organization.