Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunosuppression effected by macrophage surfaces

W Ptak, R K Gershon

    Journal of Immunology (Baltimore, Md. : 1950)
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Contrasuppression in the mouse.

    Immunology today·2014
    Same author

    The influence of collagenase treatment on the production of TNF-alpha, IL-6 and IL-10 by testicular macrophages.

    Journal of immunological methods·2005
    Same author

    Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation.

    Inflammation·2004
    Same author

    Topical tacrolimus and cyclosporin A differentially inhibit early and late effector phases of cutaneous delayed-type and immunoglobulin E hypersensitivity.

    Immunology·2001
    Same author

    Cross-reactivity of TNP immune effector T cells that mediate contact hypersensitivity and inflammatory bowel disease in the mouse.

    International archives of allergy and immunology·2001
    Same author

    [Chronic inflammation of the colon: a diagnostic problem].

    Przeglad lekarski·2000
    Same journal

    Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    An MR1-specific nanobody capable of blocking MR1T cell activation.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    TGF-β controls developmental fate and functional identity of thymic γδ T cells.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    Distinguishing Th17 cells as a unique subset.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    See all related articles

    Heat-killed macrophages suppress immune cell cooperation in Mishell-Dutton cultures. This suppression is linked to inactivating receptors for cytophilic antibodies, suggesting macrophages absorb essential factors.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Macrophage functions in immune regulation are complex.
    • Understanding cellular interactions is crucial for immune response.
    • Mishell-Dutton cultures model B-cell antibody production.

    Purpose of the Study:

    • To investigate the suppressive effect of heat-killed macrophages on Mishell-Dutton cultures.
    • To elucidate the mechanism behind macrophage-mediated suppression.
    • To determine the role of cytophilic antibody receptors in this process.

    Main Methods:

    • Mishell-Dutton cultures were established.
    • Heat-killed macrophages and six other cell types were introduced.
    • Cell viability was assessed.
    • Treatments inactivating cytophilic antibody receptors were applied.

    Related Experiment Videos

    Main Results:

    • Heat-killed macrophages, but not other tested cell types, suppressed Mishell-Dutton cultures.
    • The suppressive effect did not compromise cell viability.
    • Treatments targeting cytophilic antibody receptors abolished the suppression.

    Conclusions:

    • Macrophages possess a unique suppressive capacity in lymphocyte cooperation.
    • This suppression mechanism involves the inactivation of factors necessary for lymphocyte cooperation.
    • Macrophages may absorb and neutralize key factors via cytophilic antibody receptors.