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Dopaminergic gene expression during amphetamine withdrawal

A M Persico1, C W Schindler, M T Brannock

  • 1Addiction Research Center, NIDA, Baltimore, MD 21224.

Neuroreport
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Amphetamine withdrawal in rats alters gene expression in dopaminergic systems. Tyrosine hydroxylase (TH) mRNA increased, while synaptic vesicle amine transporter (SVAT) expression decreased, potentially aiding neuronal recovery.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Psychostimulant administration cessation induces behavioral and neurochemical changes.
  • Dopaminergic systems are implicated in the rewarding effects of psychostimulants and may be affected during withdrawal.

Purpose of the Study:

  • To investigate the impact of chronic amphetamine withdrawal on the gene expression of key dopaminergic system components.
  • To determine if tyrosine hydroxylase (TH), dopamine transporter (DAT), and synaptic vesicle amine transporter (SVAT) gene expression are altered during amphetamine withdrawal.

Main Methods:

  • Rats received daily intraperitoneal amphetamine injections for two weeks.
  • Gene expression levels of TH, DAT, and SVAT were analyzed one week after the final amphetamine dose.

Related Experiment Videos

  • Dopamine levels and behavioral responses to novelty were also assessed.

    • Main Results:

    • No significant changes were observed in rat dopamine transporter (DAT) mRNA levels.
    • Tyrosine hydroxylase (TH) mRNA levels showed a modest enhancement during withdrawal.
    • Synaptic vesicle amine transporter (SVAT) expression was significantly blunted following chronic amphetamine treatment.

    Conclusions:

    • Amphetamine withdrawal alters the expression of specific genes within the dopaminergic system.
    • Modulated TH and/or SVAT gene expression may play a role in the neurobiological adaptation and recovery processes following amphetamine withdrawal.