Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphic tandem repeat region in interleukin-1 alpha intron 6

S Bailly1, F S di Giovine, G W Duff

  • 1University Department of Medicine, Royal Hallamshire Hospital, Sheffield, UK.

Human Genetics
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep apnoea phenotypes in women: A cluster analysis from the ESADA cohort.

Sleep medicine·2024
Same author

Nivolumab in patients with advanced renal cell carcinoma in France: interim results of the observational, real-world WITNESS study.

ESMO open·2024
Same author

Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors.

Angiogenesis·2024
Same author

Measles in vulnerable populations: An outbreak in Roma settlements of Loire-Atlantique, France, 2019.

Journal of medical virology·2023
Same author

Pediatric pulmonary arterial hypertension due to a novel homozygous GDF2 missense variant affecting BMP9 processing and activity.

American journal of medical genetics. Part A·2023
Same author

[Dysfunction of endothelial BMP-9 signaling in pulmonary vascular disease].

Revue des maladies respiratoires·2023

High genetic polymorphism was found in the sixth intron of the human interleukin-1 alpha gene among Caucasians. This variation, likely due to tandem repeats, offers insights into genetic diversity and potential regulatory elements.

Area of Science:

  • Genetics
  • Molecular Biology
  • Human Genomics

Background:

  • The human interleukin-1 alpha (IL-1A) gene plays a crucial role in inflammatory responses.
  • Understanding genetic variations within gene introns can provide insights into gene regulation and population genetics.

Purpose of the Study:

  • To analyze the polymorphism of the sixth intron of the human IL-1A gene.
  • To characterize the genetic diversity within this specific gene region in a Caucasian population.

Main Methods:

  • Polymerase chain reaction (PCR) amplification of the sixth intron of the human IL-1A gene.
  • Analysis of PCR products to identify and quantify allelic variations.

Main Results:

  • A high level of polymorphism was detected in the sixth intron of the IL-1A gene (polymorphism information content = 0.51).

Related Experiment Videos

  • Seven distinct alleles were identified, with fragment sizes ranging from 620 to 1220 base pairs.
  • The observed polymorphism is likely caused by a variable number of 46-bp tandem repeats within the intron.

    • Conclusions:

    • The sixth intron of the human IL-1A gene is highly polymorphic in Caucasian populations.
    • The polymorphism is associated with variable numbers of tandem repeats, which may contain regulatory sequences.
    • This finding contributes to the understanding of genetic variation in immune-related genes.