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Related Experiment Videos

Urinary trehalase activity in chronic glomerulonephritis

T Niwa1, T Katsuzaki, T Yazawa

  • 1Department of Internal Medicine, Nagoya University Branch Hospital, Japan.

Nephron
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Urinary trehalase shows elevated excretion in chronic glomerular disease, particularly nephrotic syndrome, indicating its potential as a sensitive biomarker for kidney damage. This enzyme is more frequently elevated than other markers of tubular damage.

Area of Science:

  • Nephrology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Chronic glomerular diseases, including glomerulonephritis and nephrotic syndrome, represent significant causes of kidney damage.
  • Accurate diagnostic markers are crucial for early detection and management of these conditions.
  • Existing urinary markers for tubular damage have limitations in sensitivity and specificity.

Purpose of the Study:

  • To investigate the diagnostic utility of urinary trehalase as a biomarker in patients with chronic glomerular diseases.
  • To compare the excretion levels of urinary trehalase with other established urinary markers of kidney damage.

Main Methods:

  • Urinary trehalase activity was measured in patients with chronic glomerulonephritis, nephrotic syndrome, and chronic renal failure.

Related Experiment Videos

  • Other urinary markers including N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), alkaline phosphatase (ALP), gamma-glutamyltranspeptidase (gamma-GTP), lactate dehydrogenase (LDH), lysozyme, and beta 2-microglobulin (BMG) were also assessed.
  • Statistical analysis was performed to correlate trehalase activity with clinical parameters and other biomarkers.

    • Main Results:

    • Urinary trehalase activity was significantly elevated in patients with chronic glomerular disease, especially nephrotic syndrome, compared to healthy controls.
    • Elevated trehalase excretion was observed in 52% of chronic glomerular disease patients, a higher incidence than other measured markers like NAG.
    • Urinary trehalase levels correlated significantly with urinary protein, NAG, AAP, and the overall score of tubular damage.

    Conclusions:

    • Urinary trehalase demonstrates potential as a sensitive biomarker for detecting kidney damage in chronic glomerular diseases.
    • Elevated trehalase excretion suggests tubular involvement, often preceding or accompanying glomerular pathology.
    • Trehalase may offer a more sensitive indicator of tubular damage compared to other commonly used urinary enzymes.