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Long-term malaria prophylaxis with weekly mefloquine

H O Lobel1, M Miani, T Eng

  • 1Malaria Branch, Centers for Disease Control, Atlanta, Georgia 30333.

Lancet (London, England)
|April 3, 1993
PubMed
Summary
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Weekly mefloquine prophylaxis is highly effective against chloroquine-resistant malaria for US Peace Corps volunteers. This malaria prevention method showed superior efficacy and good tolerance compared to other drug regimens.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Chloroquine-resistant Plasmodium falciparum malaria necessitates alternative prophylaxis.
  • Mefloquine use increased among Peace Corps volunteers in sub-Saharan Africa.

Purpose of the Study:

  • To compare the effectiveness and tolerance of long-term mefloquine prophylaxis against other antimalarial drug regimens.

Main Methods:

  • Comparative study involving Peace Corps volunteers in sub-Saharan Africa.
  • Evaluation of weekly chloroquine, weekly mefloquine, bi-weekly mefloquine, and weekly chloroquine plus daily proguanil.
  • Monitoring of Plasmodium falciparum infection incidence and adverse reaction rates.

Main Results:

Related Experiment Videos

  • Weekly mefloquine demonstrated significantly higher effectiveness (94% vs. chloroquine).
  • Mefloquine was also more effective than chloroquine plus proguanil and bi-weekly mefloquine.
  • No serious adverse events were reported; mild events were comparable to chloroquine and decreased over time.

    • Conclusions:

    • Mefloquine is a highly effective and well-tolerated option for malaria prophylaxis.
    • Recommended for both short-term and long-term travelers in malaria-endemic areas.