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Effects of calcium chelators on intracellular calcium and excitotoxicity
1Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
Neuroscience Letters
|February 19, 1993
Abstract:
In an attempt to probe the relationship between excitotoxicity and increases in intracellular calcium ([Ca2+]i), BAPTA-AM and its analogs were applied to cultured hippocampal neurons. Chelation of [Ca2+]i depressed and prolonged transient responses to glutamate and did not effect elevation of [Ca2+]i by prolonged exposure. This explains the inability of the chelators to prevent glutamate-induced toxicity.