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Amisulpride evaluation by radioreceptor assay comparison with HPLC procedure after single administration in the
1Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, Lille, France.
Methods and Findings in Experimental and Clinical Pharmacology
|January 1, 1993
Abstract:
A radioreceptor assay (RRA) was developed to determine plasma levels of amisulpride. In in vitro binding conditions, the RRA technique was sensitive (11.6 nmol/l) and reliable, with a high degree of precision. The reproducibility of the method through statistical coefficients was < 7%. This method was applied to a pilot pharmacokinetic study in rabbits following single i.v. administration of amisulpride at 10 mg/kg. The results obtained were compared with those obtained by high performance liquid chromatography method (HPLC) in order to assess the validity of this new RRA technique.