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Traumatic root resorption in dentine-immunized mice

T T Wheeler1, S E Stroup

  • 1Department of Orthodontics, University of Florida College of Dentistry, Gainesville.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|April 1, 1993
PubMed
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This study investigated if antibodies to dentin cause root resorption. Dentin-immunized mice showed no root resorption, suggesting antibodies to dentin do not cause this condition.

Area of Science:

  • Immunology
  • Dental Research
  • Mouse Models

Background:

  • Traumatic root resorption in mice correlates with decreased serum antibodies to dentin.
  • A hypothesis suggests dentin antibodies mediate root resorption.

Purpose of the Study:

  • To investigate the relationship between hyperimmunization with dentin and traumatic root resorption in mice.
  • To test the hypothesis that elevated dentin antibody titers correlate with root resorption.

Main Methods:

  • Mice were hyperimmunized with mouse and rat dentin extracts.
  • Serum samples were analyzed for antibody-to-dentin antigen using ELISA.
  • Traumatic root resorption was induced via cryoprobe and quantified using scanning electron microscopy.

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Main Results:

  • Dentin-immunized mice did not exhibit root resorption after cryoprobe injury.
  • Sham-immunized control mice showed root resorption.
  • A trend towards increased serum antibody titers to dentin was observed in immunized mice.

Conclusions:

  • Elevated antibody titers to dentin did not correlate with increased root resorption in this mouse model.
  • The findings do not support the hypothesis that dentin antibody-mediated immunity causes traumatic root resorption.