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Serum creatine phosphokinase elevations in patients with tardive dyskinesia
M F Egan1, A A Dargham, D G Kirch
1Neuropsychiatry Branch, NIMH Neuroscience Research Center, St Elizabeth's, Washington, DC 20032.
Summary
Tardive dyskinesia (TD) may cause muscle damage, indicated by elevated creatine phosphokinase (CPK) levels. This association is particularly noted in severe TD cases, especially those with dystonia, suggesting striated muscle pathology.
Area of Science:
- Neurology
- Biochemistry
Background:
- Tardive dyskinesia (TD) is a movement disorder often associated with antipsychotic medication use.
- Muscle pathology in TD is not fully understood, necessitating further investigation into potential biomarkers.
Observation:
- A case of severe TD with significant serum creatine phosphokinase (CPK) level increases was observed.
- Review of eight additional patients with severe TD identified three with mild CPK elevations.
Findings:
- Elevated CPK levels correlate with severe TD exacerbations.
- The presence of dystonia in TD cases may be linked to striated muscle pathology.
Implications:
- CPK elevation could serve as a potential indicator of muscle involvement in TD.
- These findings suggest a need for monitoring muscle health in patients with TD, particularly those with dystonia.