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Norplant use by women with sickle cell disease
O A Ladipo1, A G Falusi, P J Feldblum
1College of Medicine, University of Ibadan, Nigeria.
Objective:
To assess the safety of Norplant contraceptive implant use by women with mild-moderate homozygous sickle cell disease (HbSS).
Method:
Prospective observation of women pre- and post-insertion of Norplant, with each woman serving as her own control.
Participants:
25 women 18-40 years of age who attended a hospital sickle cell clinic; post-insertion data were available for 23 women.
Outcome Measures:
Changes in hematologic parameters including PCV, MCV, reticulocytes, ISCs, HbF and bilirubin; changes in biochemical parameters including HDL cholesterol, aspartate transaminase, alkaline phosphate, serum creatinine and serum albumin.
Result:
With a mean follow-up of 12.4 months (range 1-29 months), there were no clinically or statistically significant group or individual changes in the hematologic or biochemical parameters after Norplant insertion.
Conclusion:
Norplant appears to be a safe and appropriate contraceptive for women with mild-moderate HbSS disease.