Related Experiment Video
Updated: Oct 11, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
[Chronic inflammation 30 years after tibial intramedullary nailing--foreign body reaction or bacterial infection?]
O Grauhan1, J Hierholzer, A Speitling
1Chirurgische Klinik und Poliklinik, Universitätsklinikum Rudolf Virchow.
Abstract:
30 years after two-fold marrow nailing of the tibia due to the formation of a pseudarthrosis and timely removal of the implants in a miner who was 17 years of age at that time, we found a chronic irritation that required surgical therapy. After excision of a two inch long sequester and escape of a small and cheesy core without identification of germs the patient is symptom-free since one and a half year. A foreign-body reaction to corrosion products of the implant or a late infection with low-virulent germs of the bradytrophic medullary callus appears to be the underlying cause.
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