[Concentration of ciprofloxacin in bone tissue]

Area of Science:

• Pharmacokinetics and Drug Distribution
• Bone Metabolism and Infection
• Orthopedic Surgery and Antibiotic Prophylaxis

Context:

• Hip joint endoprosthesis implantation is a common orthopedic procedure.
• Preventing surgical site infections, particularly those involving Staphylococcus aureus, is crucial.
• Understanding antibiotic penetration into bone tissue is vital for effective prophylaxis.

Purpose:

• To quantify ciprofloxacin concentrations in human cancellous and cortical bone after intravenous administration.
• To compare bone concentrations with serum levels and the minimum inhibitory concentration (MIC90) for Staphylococcus aureus.
• To evaluate the potential of ciprofloxacin as a prophylactic agent in hip replacement surgery.

Summary:

• This study measured ciprofloxacin levels in bone and serum of 20 patients undergoing hip replacement surgery.
• Ciprofloxacin demonstrated rapid penetration into both cancellous and cortical bone tissue.
• In most samples, bone concentrations exceeded the MIC90 for Staphylococcus aureus, suggesting potential for infection prevention.

Impact:

• Provides crucial pharmacokinetic data on ciprofloxacin bone penetration in orthopedic patients.
• Supports the use of ciprofloxacin for antibiotic prophylaxis in hip arthroplasty.
• Informs optimal dosing strategies to achieve therapeutic concentrations in bone tissue.