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Age related changes in functions and physicochemical properties of rat jejunal brush border membrane after chronic
C Lindi1, P Marciani, F Omodeo-Sale
1Institute of General Physiology and Biochemistry, University of Milano, Italy.
Abstract:
1. We investigated the chronic effects of a 4 week treatment with ethanol on functions and physicochemical properties of BBM of young and adult rats (2 and 7 months old respectively). 2. In the ethanol treated groups the cholesterol/phospholipid and the protein/lipid ratios as well as the D-glucose uptake and lactase specific activity and Vmax were increased. In spite of a minor alcohol consumption the adult group was the more affected. 3. Membranes from the ethanol fed rats were less fluid and more tolerant to the in vitro addition of ethanol.