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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta
G R Standen1, F J Steers, L Jones
1Department of Haematology, Bristol Royal Infirmary.
Aims:
To determine whether myeloid proliferation was monoclonal or polyclonal in a woman with chronic neutrophilic leukaemia and myeloma.
Methods:
The X-linked probe, M27 beta was used to determine the clonality of the neutrophil population by analysis of restriction fragment length polymorphisms and X inactivation pattern.
Results:
A polyclonal pattern of X inactivation was obtained for the neutrophil population in this patient.
Conclusion:
The myeloid expansion in chronic neutrophilic leukaemia associated with myeloma represents a polyclonal reactive response to the plasma cell clone rather than a co-existent myeloproliferative disorder.
