Neurotransmission in the brain by diffusion through the extracellular fluid: a review
1Department of Rehabilitation Medicine, University of Wisconsin, Madison 53706.
Abstract:
Synaptic or 'hard wired' neurotransmission in the brain, subject to modulation by a class of substances called modulators, has been the dominant model of brain function. However, increasing evidence for alternate non-synaptic neurotransmission mechanisms is forcing consideration of a more inclusive model. Evidence is presented for such neurotransmitter systems that require diffusion through the extracellular fluid. Old and new findings have been interpreted within a conceptual framework that is not centered on the synaptic model, but instead considers a continuum of neurotransmitter actions.
Related Concept Videos
The Blood-brain Barrier
The Synapse
Excitatory and Inhibitory Effects of Neurotransmitters
Neurochemical Transmission: Sites of Drug Action
Electrochemical Gradient and Channel Proteins: An Overview
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Neuronal Communication


