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Elemental diet-induced bacterial translocation can be hormonally modulated
1Department of Surgery, Louisiana State University Medical Center, Shreveport 71130-3932.
Annals of Surgery
|June 1, 1993
Summary
Dietary fiber prevents bacterial translocation (BT) in mice fed an elemental diet. This protective effect is mediated by gut hormones, with bombesin showing benefits and sandostatin reversing them.
Area of Science:
- Gastroenterology
- Microbiology
- Endocrinology
Background:
- Elemental diets can cause bacterial translocation (BT).
- Dietary fiber prevents diet-induced BT.
- The role of gut hormones in fiber's protective effect is unclear.
Purpose of the Study:
- To investigate if fiber's protective effect against BT is mediated by trophic gut hormones.
- To examine the effects of sandostatin and bombesin on BT.
Main Methods:
- Mice were fed either chow or an elemental diet.
- Groups received bombesin or sandostatin.
- Bacterial translocation, cecal bacteria, mucosal protein, and small bowel weight were measured.
- Histological examination of the ileum and jejunum was performed.
Main Results:
- Elemental diet-induced BT (75%) was significantly reduced by fiber (9%) or bombesin (13%).
- Sandostatin reversed fiber's protective effect, increasing BT incidence to 75%.
Conclusions:
- Hormonal modulation can impact elemental diet-induced bacterial translocation.
- The beneficial effects of dietary fiber on BT appear to be hormonally mediated.