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Related Experiment Videos

Is segmentation generic?

S A Newman1

  • 1Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

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Tissue segmentation, a fundamental process in animal development, arises from differential cell adhesion and periodic molecular regulation. This generic property likely evolved multiple times, explaining diverse segmentation patterns across species.

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Biophysics

Background:

  • Cellular boundaries form when cell populations exhibit differing intercellular adhesion.
  • Periodic regulation of adhesion molecules can lead to the formation of alternating tissue segments.
  • Positive autoregulation of molecules can naturally create spatial or temporal periodicities.

Purpose of the Study:

  • To propose that tissue segmentation is a generic property of metazoan organisms.
  • To demonstrate that a simple model can explain diverse segmentation phenomena.
  • To suggest that complex segmentation systems evolved from simpler, self-organizing principles.

Main Methods:

  • A simple biophysical model based on differential adhesion and periodic adhesion regulation.

Related Experiment Videos

  • Analysis of segment properties in various organisms and experimental systems.
  • Theoretical framework for understanding evolutionary origins of segmentation.

    • Main Results:

    • Differential adhesion and periodic regulation can generate tissue boundaries and segments.
    • The model accounts for segment diversity in insects and boundary regeneration.
    • Segmentation is proposed as a generic, evolutionarily recurrent property.

    Conclusions:

    • Tissue segmentation is a fundamental, likely repeatedly evolved, property of metazoan development.
    • Complex segmentation mechanisms evolved by recruiting molecular cues to generic self-organizing tissue properties.
    • Understanding basic biophysical principles is key to deciphering evolutionary developmental biology.