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Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats
D R Malin1, J E Zadina, J R Lake
1University of Houston-Clear Lake, TX 77058.
Brain Research
|April 30, 1993
Abstract:
The endogenous neuropeptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide) has been shown to counteract various opiate actions. In the current study, third ventricular injection of 35 micrograms Tyr-MIF-1 protected by the enzyme inhibitor bestatin precipitated an abstinence syndrome in morphine-dependent rats, but not in opiate-naive rats. The results raise the possibility that Tyr-MIF-1 might participate in opiate dependence and opiate abstinence syndrome.