Stimulation of human neutrophil migration by aurothioglucose and thioglucose

Migration of human neutrophils was enhanced by aurothioglucose in a concentration-dependent manner. Migration was especially pronounced when the drug was present in the lower compartment of the Boyden chamber, suggesting that the enhancement of migration was chemotactic rather than chemokinetic. Thioglucose followed the same pattern of stimulation as the related gold compound, but the enhancement at the maximally stimulating concentration was less; at higher concentrations thioglucose inhibited random migration.