Related Experiment Video

Updated: Sep 28, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Chronic pulmonary aspiration in children

M L Bauer1, R Figueroa-Colon, K Georgeson

  • 1Department of Pediatrics, University of Alabama, Birmingham.

Southern Medical Journal
|July 1, 1993
PubMed

Insights

Diagnosing chronic pulmonary aspiration involves identifying symptoms like coughing and recurrent pneumonia. Treatment strategies range from medical interventions to surgical solutions, tailored by diagnostic findings and illness severity.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pulmonology

Background:

  • Chronic pulmonary aspiration presents with symptoms such as coughing, choking during feeding, and recurrent pneumonia.
  • Radiological evidence of chronic lung injury often accompanies failure to thrive in affected individuals.

Purpose of the Study:

  • To outline established diagnostic and therapeutic guidelines for chronic pulmonary aspiration.
  • To detail various diagnostic modalities and treatment options for aspiration.

Main Methods:

  • Clinical suspicion is raised by specific symptoms and radiological findings.
  • Diagnostic tools include upper gastrointestinal series, gastroesophageal scintigraphy, lipid-laden macrophage index, and esophageal pH probe.
  • Therapeutic interventions encompass medical management and surgical options.

Main Results:

  • Upper GI series accurately defines anatomy and function, differentiating aspiration types and predisposing conditions.
  • Gastroesophageal scintigraphy aids in differentiating aspiration types and identifying delayed gastric emptying or reflux.
  • Lipid-laden macrophage index aids aspiration identification, while esophageal pH probe detects reflux.

Conclusions:

  • Therapy is individualized based on the severity of illness and diagnostic evaluation results.
  • Treatment options range from thickened feedings and positioning to surgical interventions like gastrostomy or fundoplication.

More Related Videos

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury09:16

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Published on: February 26, 2017

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...