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Mania and Down's syndrome

S A Cooper1, R A Collacott

  • 1Frith Hospital, Leicester.

The British Journal of Psychiatry : the Journal of Mental Science
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

Mania diagnosis in individuals with Down's syndrome (DS) was previously thought impossible. This review of seven cases shows mania can occur in DS, presenting similarly to other learning disabilities but with unique features like male predominance and rapid cycling.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Historically, Down's syndrome was believed to preclude mania diagnoses.
  • Previous literature suggested atypical presentations of mania in individuals with Down's syndrome.

Purpose of the Study:

  • To review existing case reports of mania in individuals with Down's syndrome.
  • To analyze the clinical features and atypical presentations of mania in this population.

Main Methods:

  • Systematic review of seven previously reported cases of mania in individuals with Down's syndrome.
  • Analysis of clinical features, demographic data, and illness patterns.

Main Results:

  • Seven cases of mania in males with Down's syndrome were identified and reviewed.

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  • Clinical features were similar to mania in other learning disability contexts.
  • Atypical features included male predominance, absence of family history of affective disorder, and rapid cycling in two cases.

    • Conclusions:

    • Mania can occur in individuals with Down's syndrome.
    • Atypical features warrant further investigation into potential underlying mechanisms such as hypothyroidism and monoamine biochemistry.