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CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity
1Department of Physiology, Flinders University of South Australia, Bedford Park.
Brain Research
|May 28, 1993
Abstract:
Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.