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Updated: Aug 19, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
[Tendency of development on novel type of cardiotonic drugs]
1Department of Pharmaceutical Molecular Biology, Tohoku University.
Abstract:
The narrow margin of safety of cardiotonic glycosides has led to extensive studies for novel cardiotonic agents that are superior to the glycosides. Cardiotonic drugs acting on beta-adrenoceptors and inhibitors of cAMP phosphodiesterase have been extensively studied and used for the treatment of heart failure. Ca sensitizers are of interest, since such a mechanism of action may be beneficial for the failing heart. Recently, cardiotonic substances with a novel mechanism of action such as gingerol and xestoquinone have been isolated from natural sources. Furthermore, 9-methyl-7-bromoeudistomin D, a powerful radiolabeled Ca2+ releaser having caffeine-like properties, may provide a promising tool for studying the molecular mechanism of the Ca2+ release process.
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