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Related Experiment Videos

Canine aflatoxicosis

P J Ketterer, E S Williams, B J Blaney

    Australian Veterinary Journal
    |July 1, 1975
    PubMed
    Summary

    Aflatoxin poisoning from moldy bread caused a dog

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    Area of Science:

    • Veterinary Toxicology
    • Mycotoxicology
    • Animal Pathology

    Background:

    • Aflatoxins are toxic secondary metabolites produced by Aspergillus species.
    • Contaminated feed poses a significant risk to animal health.
    • Mouldy bread can be a source of aflatoxin contamination.

    Purpose of the Study:

    • To investigate the cause of death in dogs consuming moldy bread.
    • To confirm aflatoxin poisoning as the etiological agent.
    • To characterize the pathological findings associated with aflatoxin ingestion.

    Main Methods:

    • Necropsy and histopathological examination of affected dogs.
    • Isolation of Aspergillus flavus from feed and biological samples.
    • Quantification of aflatoxins (B1 and G1) in food and vomitus using analytical chemistry techniques.

    Main Results:

    • One dog's death was confirmed due to aflatoxin poisoning; two others were suspected.
    • Gross findings included jaundice, bile-stained liver, and gastrointestinal hemorrhage.
    • Histopathology revealed hepatocellular fatty changes, bile duct proliferation, and necrosis.
    • High levels of aflatoxin B1 (6.7 ppm in bread, 100 ppm in vomitus) and G1 (40 ppm in vomitus) were detected.

    Conclusions:

    • Moldy bread contaminated with aflatoxins can be lethal to dogs.
    • Aflatoxin poisoning presents with characteristic pathological changes in the liver and gastrointestinal tract.
    • Prompt identification and removal of contaminated feed are crucial to prevent further fatalities.

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