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Striatal [11C]-N-methyl-spiperone binding in patients with focal dystonia (torticollis) using positron emission
K Leenders1, P Hartvig, L Forsgren
1Paul Scherrer Institute, Villigen, Switzerland.
Abstract:
Specific binding of [11C]-N-methyl-spiperone to striatal dopamine D2 receptors was assessed using positron emission tomography (PET) in 6 patients with adult-onset focal dystonia (predominantly spasmodic torticollis) and in 5 healthy subjects. No significant difference in average specific striatal tracer uptake between patients and healthy subjects was found. However, in the 5 patients showing lateralisation of clinical signs a trend to higher striatal tracer uptake in the contralateral hemisphere was observed.