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Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses
D L Price1, D R Borchelt, S S Sisodia
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
Abstract:
Alzheimer disease and the prion disorders/spongiform encephalopathies share many common features. These chronic, progressive, sometimes familial diseases of the central nervous system are characterized by the presence of different types of amyloid deposits in the brain. This review provides a perspective on these two types of neurodegenerative disorders.