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Circulatory and respiratory effects of the combination medetomidine-ketamine in beagles
D Serteyn1, P Coppens, R Jones
1Service d'Anesthésiologie, Faculté de Médecine Vétérinaire Université de Liège, Belgium.
Journal of Veterinary Pharmacology and Therapeutics
|June 1, 1993
Abstract:
The cardiovascular and respiratory parameters of eight laboratory beagles were measured before and after the simultaneous injection of medetomidine (40 micrograms/kg bw) and ketamine (5 mg/bg bw). This combination produced a significant alteration in cardiovascular function. The heart rate, the stroke volume and cardiac output decreased while the systemic vascular resistance increased. These effects were attributed principally to the alpha 2 agonist compound combined with the moderate stimulatory effect of ketamine. The respiratory parameters were little affected by this protocol.