Related Experiment Videos
Identification of class II major histocompatibility complex polymorphisms predicted to be important in peptide
G T Pharr1, H D Hunt, L D Bacon
1Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823.
Abstract:
Chickens of the B2, B5, B15, B19, and B21 B-congenic haplotypes differ in disease resistance. Complementary DNA from B-congenic chicken strains have been analyzed for allelic diversity of expressed Class II MHC genes. The predicted amino acid sequences of eight genes from five haplotypes were subjected to Wu-Kabat variability analysis. The B-L gene polymorphic regions and conserved regions are highly similar to the human leukocyte antigen Class II genes. Therefore, the present analysis reveals candidate polymorphisms important in determining the spectrum of antigenic peptides presented to T helper cells, and allelic differences possibly important in resistance to avian disease.