Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective differentiation of CD4+ T helper cell subsets

P Scott1

  • 1School of Veterinary Medicine, University of Pennsylvania, Philadelphia.

Current Opinion in Immunology
|June 1, 1993
PubMed
Summary

Recent research shows innate immune signals (cytokines) are crucial for CD4 T helper cell differentiation. Antigen-presenting cells, epitopes, and antigen concentration also influence the selective development of specific T helper cell subsets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Hull mechanical thrombectomy (MT) model: interventional radiologists performing mechanical thrombectomy for acute ischaemic stroke in the United Kingdom. Training, governance and beyond, with a propensity score matching analysis of outcomes.

Clinical radiology·2026
Same author

Radiometer calibration using machine learning.

Scientific reports·2025
Same author

Receiver design for the REACH global 21-cm signal experiment.

Experimental astronomy·2025
Same author

Comparative evaluation of PCR and loop-mediated isothermal amplification (LAMP) assays for detecting <i>Pasteurella multocida</i> in poultry.

New Zealand veterinary journal·2024
Same author

What are the 100 most cited fungal genera?

Studies in mycology·2024
Same author

Cardiac sympathetic denervation and anxiety in Parkinson disease.

Parkinsonism & related disorders·2024

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD4 T helper cells orchestrate adaptive immunity.
  • Understanding T helper cell subset differentiation is key to controlling immune responses.

Purpose of the Study:

  • To summarize recent advances in understanding CD4 T helper cell subset differentiation.
  • To highlight the role of innate immune signals and antigen-specific factors.

Main Methods:

  • Review of recent immunological studies.
  • Analysis of cytokine signaling pathways.
  • Investigation of antigen-presenting cell interactions.

Main Results:

  • Innate immune signals (cytokines) are critical drivers of T cell subset differentiation.
  • Antigen-presenting cells influence the selection of specific T helper cell subsets.
  • Antigenic epitope and concentration modulate T helper cell development.

Conclusions:

  • Significant progress has been made in identifying key factors in CD4 T helper cell differentiation.
  • Cytokines from the innate immune response play a pivotal role.
  • Antigen-specific parameters are also important for selective T helper cell subset development.

Related Experiment Videos