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Mycobacterium celatum sp. nov

W R Butler1, S P O'Connor, M A Yakrus

  • 1Division of Bacterial and Mycotic Diseases, Centers for Diseases Control and Prevention, Atlanta, Georgia 30333.

International Journal of Systematic Bacteriology
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

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A new Mycobacterium species, Mycobacterium celatum, has been identified. This slowly growing, nonphotochromogenic bacterium is clinically significant and resistant to many tuberculosis drugs.

Area of Science:

  • Microbiology
  • Mycobacteriology
  • Clinical Infectious Diseases

Background:

  • The Mycobacterium genus includes clinically significant pathogens.
  • Distinguishing between slowly growing nonphotochromogenic mycobacteria is challenging.
  • Previous classifications relied on biochemical and genetic markers, necessitating new approaches.

Purpose of the Study:

  • To describe and characterize a novel, slowly growing, nonphotochromogenic Mycobacterium species.
  • To differentiate this new species from known Mycobacterium xenopi and Mycobacterium avium complex members.
  • To propose a new species name and provide reference strains for identification.

Main Methods:

  • Biochemical characterization and drug susceptibility testing.
  • Multilocus enzyme electrophoresis (MEE) for genetic typing.

Related Experiment Videos

  • Thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), and gas-liquid chromatography (GLC) for mycolic acid and fatty acid analysis.
  • 16S rRNA gene sequencing for phylogenetic analysis.

    • Main Results:

    • The new species, Mycobacterium celatum, exhibited biochemical similarity to M. xenopi and M. avium complex but was genetically distinct.
    • Strains were resistant to most antituberculosis drugs.
    • MEE revealed unique electrophoretic types, supporting its status as a new species.
    • Mycolic acid and fatty acid profiles (TLC, HPLC, GLC) were distinct from other described Mycobacterium species.
    • 16S rRNA sequencing confirmed its phylogenetic placement among slowly growing mycobacteria.

    Conclusions:

    • Mycobacterium celatum is a distinct, clinically important species of slowly growing mycobacteria.
    • Its unique biochemical and genetic characteristics, including drug resistance, necessitate specific diagnostic and therapeutic considerations.
    • Reference strains ATCC 51130 and ATCC 51131T are available for further study and identification.