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Coherent network oscillations by olfactory interneurons: modulation by endogenous amines

A Gelperin¹, L D Rhines, J Flores

¹Biological Computation Research Department, AT&T Bell Laboratories, Murray Hill, New Jersey 07974.

Journal of Neurophysiology

|June 1, 1993

Summary

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The Limax maximus procerebral lobe generates a 0.7-Hz olfactory oscillation modulated by odorants. Dopamine and serotonin increase oscillation frequency, while glutamate suppresses it, suggesting roles in olfactory learning and plasticity.

Area of Science:

Neuroscience
Olfactory System Research
Molluscan Neurobiology

Background:

The procerebral (PC) lobe of Limax maximus processes olfactory information.
This lobe contains a network of interneurons receiving input from olfactory organs.
A coherent 0.7-Hz oscillation in the local field potential (LFP) is characteristic of this network.

Purpose of the Study:

To investigate the modulation of the PC lobe's olfactory oscillation by neurotransmitters.
To explore the potential role of these modulations in olfactory learning and synaptic plasticity.

Main Methods:

Recording of local field potentials (LFPs) in the PC lobe of Limax maximus.
Application of natural odorants, dopamine, serotonin, and glutamate to the olfactory system.

Related Experiment Videos

Analysis of changes in oscillation frequency, waveform, and receptor mechanisms.

Main Results:

Natural odorants modulate the PC lobe's 0.7-Hz LFP oscillation.
Dopamine and serotonin increase the oscillation frequency and alter its waveform.
Glutamate, acting via a quisqualate-type receptor, suppresses the oscillation and may be involved in generating the basic rhythm.

Conclusions:

Neurotransmitters like dopamine and serotonin influence the olfactory network's oscillatory activity.
These modulations suggest a role for amines in synaptic plasticity within the olfactory system, paralleling vertebrate systems.
The oscillatory network may underlie Limax's advanced odor recognition and learning capabilities.