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Glaphenine-containing gallstones

C Moesch1, M Daudon, J Leymarie

  • 1Laboratoire de Chimie Organique Pharmaceutique, Faculté de Pharmacie, Limoges, France.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|May 1, 1993
PubMed
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Glaphenine, an analgesic, can form radiolucent bile duct stones in patients with arthritis. Analysis confirmed glaphenine as the primary component in these drug-induced gallstones.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Analytical Chemistry

Background:

  • Glaphenine is an anthranilic acid-derived analgesic.
  • Long-term glaphenine use is associated with arthrosic conditions.
  • Bile duct stones are a potential complication.

Purpose of the Study:

  • To analyze the composition of common bile duct stones in patients treated with glaphenine.
  • To investigate the role of glaphenine in gallstone formation (lithogenesis).
  • To highlight the possibility of drug-induced, radiolucent gallstones.

Main Methods:

  • Infrared spectroscopy
  • High-performance thin-layer chromatography (HPTLC)
  • Scanning electron microscopy (SEM)
  • Energy-dispersive X-ray analysis (EDAX)

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Main Results:

  • Common bile duct stones were found to contain glaphenine acid.
  • Analysis confirmed drug compounds as the main component of the stones.
  • The stones were radiolucent, indicating a non-calcium composition.

Conclusions:

  • Glaphenine can lead to the formation of radiolucent gallstones.
  • Drug compounds should be considered in the etiology of certain gallstones.
  • Analytical techniques are crucial for identifying drug-induced stones.