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Human leukocyte antigen in hydatidiform mole
1Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.
Objective:
To find any possible association between human leukocyte antigen (HLA) as a genetic marker and the development of hydatidiform mole (HM).
Method:
The lymphocyte microtoxicity technique was used to study the HLA antigens in 3 groups: 18 women with hydatidiform mole and their husbands (study group), 300 normal women (first control group), and 20 normal pregnant women and their husbands (second control group).
Result:
Hydatidiform mole is more frequent in women having HLA A1. The disease is more common in couples with partial compatibility of the B locus.
Conclusion:
HM occurs more frequently in women with certain HLA antigens and when the husband and wife have partial compatibility at the B locus.
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