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Somatostatin: the early days

R Guillemin1

  • 1Whittier Institute, La Jolla, CA 90608.

Digestion
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Researchers discovered somatostatin, a growth hormone secretion inhibitor, unexpectedly inhibiting insulin and glucagon. This hormone was later found in pancreatic delta cells.

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Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Cell Biology

Background:

  • The discovery of somatostatin originated from research efforts to identify a growth hormone-releasing factor.
  • Initial investigations focused on somatostatin's role as a growth hormone inhibitor.

Discussion:

  • Somatostatin was unexpectedly found to inhibit the secretion of both insulin and glucagon.
  • This discovery highlighted somatostatin's broader regulatory functions beyond growth hormone.

Key Insights:

  • Somatostatin's multifaceted inhibitory role in endocrine secretion was uncovered.
  • The localization of somatostatin within the delta cells of pancreatic islets was a significant finding.

Outlook:

  • Further research into somatostatin's diverse physiological roles and therapeutic potential is warranted.
  • Understanding somatostatin's regulation of pancreatic hormone secretion may offer new insights into metabolic disorders.