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Fibrin adhesive in radical mastectomy
P Udén1, K Aspegren, G Balldin
1Department of Surgery, Malmö Allmänna sjukhus, Lund University, Sweden.
Summary
Fibrin adhesive glue did not reduce seroma formation after breast cancer surgery. This study found no significant difference in seroma incidence between patients treated with fibrin glue and those in the control group.
Area of Science:
- Oncology
- Surgical Innovation
- Biomaterials
Background:
- Seroma formation is a common complication following modified radical mastectomy for breast cancer.
- Effective prevention strategies are crucial for improving patient outcomes and reducing healthcare costs.
Purpose of the Study:
- To evaluate the efficacy of local fibrin adhesive glue application in reducing the incidence of seroma after modified radical mastectomy.
- To assess the impact of fibrin glue on postoperative drainage, aspiration volumes, and hospital stay.
Main Methods:
- Prospective randomized study conducted at a city hospital in Sweden.
- 68 women undergoing modified radical mastectomy with axillary clearance were included.
- Outcomes measured included seroma incidence, volume of aspirations, and length of hospital stay.
Main Results:
- Seromas developed in 59% of patients (40/68).
- Incidence was similar between the fibrin adhesive group (64%) and the control group (53%), with no statistically significant difference (p=0.5).
- No significant differences were observed in aspiration volumes or hospital stay between the groups.
Conclusions:
- Local application of fibrin adhesive glue does not effectively reduce the incidence of seroma formation after modified radical mastectomy.
- Further research may be needed to explore alternative or adjunctive methods for seroma prevention.