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Related Experiment Videos

Flow velocity studies in vein pouch model aneurysms

T Hashimoto1

  • 1Aneurysm Research Laboratory, University of California, Santa Barbara.

Neurological Research
|June 1, 1993
PubMed
Summary

This study experimentally measured blood flow velocity and pressure in model aneurysms. Findings indicate that turbulent flow and high pressure waves within aneurysms may contribute to their growth and rupture.

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Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cardiovascular Research

Background:

  • Cerebral aneurysms are vascular abnormalities with poorly understood growth and rupture mechanisms.
  • Previous research on aneurysm hemodynamics has been largely theoretical.
  • Experimental data on intra-aneurysmal flow patterns is lacking.

Purpose of the Study:

  • To experimentally measure velocity profiles and pressure waveforms within model aneurysms.
  • To investigate the role of hemodynamic factors in aneurysm development.
  • To compare hemodynamic parameters between aneurysms and parent vessels.

Main Methods:

  • Utilized a vein grafted aneurysm model for experimental investigation.
  • Employed a constant temperature hot-film anemometer for velocity measurements.
  • Used a high-frequency pulsed directional ultrasonic Doppler for flow and pressure waveform analysis.

Main Results:

  • Detected turbulent blood flow at the neck and body of the model aneurysms.
  • Observed distorted flow patterns and high-pressure pulse waves within the aneurysms.
  • Demonstrated significant differences in pressure waveforms compared to the parent vessel.

Conclusions:

  • Turbulent flow and elevated pressure pulse waves are significant findings within model aneurysms.
  • These hemodynamic factors likely play a critical role in the growth and rupture of cerebral aneurysms.
  • The study provides experimental evidence supporting hemodynamic theories of aneurysm progression.

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