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Intercellular signalling in mesoderm formation during amphibian development

J C Smith1, V Cunliffe, J B Green

  • 1Laboratory of Developmental Biology, National Institute for Medical Research, Mill Hill, London, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|June 29, 1993
PubMed
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Fibroblast growth factor (FGF) and activin signal different mesodermal cell types in amphibian embryos. Graded factor distributions can establish positional information for body plan development in Xenopus.

Area of Science:

  • Developmental biology
  • Embryology
  • Molecular signaling

Background:

  • Mesoderm formation in amphibian embryos is initiated by signals from the vegetal hemisphere.
  • Fibroblast growth factor (FGF) and activin are key candidate endogenous mesoderm-inducing signals.

Purpose of the Study:

  • To investigate the role of FGF and activin concentrations in mesodermal cell fate determination.
  • To explore the potential of graded factor distributions in establishing embryonic positional information.

Main Methods:

  • Exposure of amphibian embryonic cells to varying concentrations of FGF and activin.
  • Analysis of mesodermal cell type formation in response to different signaling levels.

Main Results:

Related Experiment Videos

  • Different concentrations of FGF and activin induce distinct mesodermal cell types.
  • Demonstrated that graded distributions of these factors can provide positional cues.

    • Conclusions:

    • Activin and FGF play crucial roles in mesoderm induction and patterning.
    • Concentration-dependent signaling by FGF and activin is a viable mechanism for generating the Xenopus body plan.