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Stress-age syndrome

V V Frolkis1

  • 1Department of Biology of Aging, Institute of Gerontology, Kiev, Ukraine.

Mechanisms of Ageing and Development
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

Aging involves a stress-age syndrome with neurohormonal and cellular changes. This syndrome includes both adaptive and damaging components, influencing stress reactions and aging complexity.

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Area of Science:

  • Gerontology
  • Neuroendocrinology
  • Cellular Biology

Background:

  • Aging is characterized by a complex interplay of neurohormonal, tissue, and cellular alterations.
  • These changes collectively define the stress-age syndrome, impacting physiological regulation.

Purpose of the Study:

  • To define and characterize the stress-age syndrome.
  • To elucidate the adaptive and damaging components of this syndrome.
  • To understand how the stress-age syndrome modifies stress reactions during aging.

Main Methods:

  • Analysis of neurohormonal changes including catecholamines, vasopressin, ACTH, cortisol, testosterone, and thyroxin.
  • Assessment of cellular changes such as immunodepression, dyslipoproteidemia, hypercoagulation, and free-radical damage.

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  • Examination of limbic system and hypothalamic excitability alterations.

    • Main Results:

    • Identified key changes in neurohormonal profiles (e.g., increased cortisol, decreased testosterone).
    • Observed cellular dysfunctions including immune suppression and oxidative stress.
    • Noted alterations in the excitability of brain regions involved in stress response.
    • Recognized that stress-age syndrome components have both adaptive and detrimental roles.

    Conclusions:

    • The stress-age syndrome encompasses a range of physiological changes contributing to the aging process.
    • While some aspects are adaptive, others are damaging, leading to complex aging phenotypes.
    • The syndrome significantly alters the organism's response to stress, highlighting its critical role in aging.