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Citalopram for post-stroke pathological crying

G Andersen1, K Vestergaard, J O Riis

  • 1Department of Neurology, Aalborg Hospital, Denmark.

Lancet (London, England)
|October 2, 1993
PubMed
Summary
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Selective serotonin reuptake inhibitors like citalopram effectively treat post-stroke pathological crying. This study found citalopram significantly reduced crying episodes and improved mood in stroke survivors.

Area of Science:

  • Neurology
  • Psychiatry
  • Pharmacology

Background:

  • Post-stroke pathological crying is a distressing neurological condition.
  • It is characterized by crying without associated mood changes, often triggered by minor stimuli.
  • Preliminary evidence suggests a link to disturbed serotoninergic neurotransmission.

Purpose of the Study:

  • To investigate the efficacy of citalopram, a selective serotonin reuptake inhibitor (SSRI).
  • To assess the effect of citalopram on uncontrolled crying in stroke patients.
  • To evaluate the safety and tolerability of citalopram in this patient population.

Main Methods:

  • A double-blind, placebo-controlled, crossover study.
  • 16 stroke patients with pathological crying were enrolled.

Related Experiment Videos

  • Patients received citalopram (10-20 mg daily) or placebo for 3-week periods.

    • Main Results:

    • Citalopram treatment led to a >50% decrease in daily crying episodes in all 13 assessable patients, compared to only 2 on placebo (p < 0.005).
    • The therapeutic effect was rapid (1-3 days) and pronounced in 73% of patients.
    • A significant decrease in depression ratings (Hamilton Depression Scale) was observed concurrently (p < 0.005).
    • Citalopram was well-tolerated, with mild and transient side-effects.

    Conclusions:

    • Serotoninergic neurotransmission plays a significant role in post-stroke pathological crying.
    • Citalopram is an effective and well-tolerated treatment for this condition.
    • SSRI treatment offers a promising therapeutic option for managing post-stroke crying.